中老年BMD减低者血微量营养素及血脂水平变化

The relationship study of micronutrients and blood lipid in serum levels in middle and senior people with low bone mineral density (BMD)

目的探讨中老年骨密度(BMD)降低患者中血维生素A、D、E,以及微量元素锌(Zn)、铁(Fe)、铜(Cu)、血脂及血浆同型半胱氨酸(Hcy)水平的变化和意义。方法采用双能X线骨密度仪检测BMD,根据结果分为42例BMD减低组和年龄、性别匹配的正常对照组41例,测定血维生素A、D、E;微量元素Zn、Fe、Cu;血脂及血浆Hcy水平。结果低BMD组血清铜/锌比值低于对照组,差异有显著性(P<0.01),而血浆同型半胱氨酸则高于对照组,组间差异有显著性(P<0.01),血铁水平两组间差异无显著性(P>0.05);低BMD组中血清甘油三酯高于正常值水平,血脂水平组间差异不显著(P>0.05);低BMD组血清25-羟维生素D3水平值较对照组低,但差异不显著(P>0.05);血浆维生素A和E水平两组均在正常范围。结论中老年低骨密度者存在血脂代谢紊乱和微量元素锌和铜的失调,血清维生素D水平尚未出现减低。

Objective To explore the relationship of vitamin A, D, E and microelement iron, zinc, copper and blood lipid and plasma homocysteine in middle and senior people with BMD, Methods BMD was measured by double energy X-ray, 102 middle and senior people were divided to group control（ n =41 ）, low BMD（ n = 42） according to the results of BMD, microelement Fe, Cu, Zn, and vitamin A, D, E and blood lipid and plasma homocysteine were measured. Results the value of Cu/Zn in low BMD group was significantly lower than control group and plasma homocysteine increased significantly （ P 〈 0.01, P 〈 0.01 ） ; There were no significant differences in serum Fe and blood lipid between two groups （ P 〉 0.05 ） ; Serum 25-dihydroxy vitamin D3 was lower than control group, but there was no significant difference （ P 〉 0.05）. VitA and VitE of two groups were all in the normal range. Conclusion The middle and senior people with low BMD had dyslipidemia, metabolism disorder of trace element Zn and Cu. The serum level of VitD decreased, but still remained in the normal range.