他汀类药物对骨形成影响的研究进展

A review on research progress of effects of statins on bone formation

他汀类药物除了可以降低血脂水平,还展现出了很多独立于降低血脂之外的其他作用。1999年Mundy等首先发现他汀类药物有促骨形成作用,其可以作为促骨形成的潜在药物而被广泛关注。随后很多学者都对他汀类药物对骨代谢的影响进行了大量的实验研究,虽然多数的研究结果支持辛伐他汀有促进骨形成和抑制骨吸收的作用,但也有部分实验未得出相同结论。为进一步研究他汀类药物在分子水平对骨代谢影响的具体作用机制,尽早研制出对骨骼具有显著作用的他汀类药物以及给药方式,是他汀类药物能否最终用于临床,治疗骨质疏松症及其他骨代谢疾病、促进骨折愈合的关键。

Besides the action on plasma lipid-lowering, statins show a series of pleiotropic effects independent from the cholesterol reduction. The ability of statins to enhance bone formation was first reported at by 1999 Mundy et al. It has recently caused widely public concern, due to the underlying stimulation of bone formation. It has been followed by many scientists performing more experimental research about the statins and bone metabolism. Although some have to hold up the effect that statins could stimulate the bone formation and inhibit the bone absorption, with conflicting results ： some have found a clear positive bone metabolic effect of statins and others have not. To further analyze their exact mechanism and confirm detailed function on bone metabolic, and discovery of bone-specific statins and their bone-targeted delivery is the key offering great potential in the treatment of osteoporosis and other metabolic diseases of bone, and in the promotion of fracture healing.