全程式管理监测及干预治疗新生儿黄疸的临床研究

Clinical study on the entire course management monitoring and interventing treatment for newborn jaundice

目的探讨全程式管理监测及干预治疗新生儿黄疸的临床意义。方法自2001～2006对ABOIgG抗A(B)≥1∶64或ABO以外抗体阳性孕妇进行干预治疗。对新生儿黄疸进行全程监测及干预治疗。结果全程监测的新生儿6267例,占出生新生儿的99.82%,以间接胆红素升高的高胆红素血症1412例,入儿科干预治疗1409例占高胆红素血症患者的97.37%。48h内检出高胆红素血症895例占高胆红素血症的63.52%,足月新生儿组、ABO溶血儿组及高危组总血清胆红素水平综合治疗前后比较有显著性差异(P<0.01)。高胆红素血症组患者(不包括告危儿)智力测试与同期出生的正常新生儿智能商比较无显著性差异(P>0.05)。结论全程式管理监测及干预治疗新生儿黄疸,对新生儿的管理更加精细化。

Objective To investigate the clinical efficacy of entire course management monitoring and interventing treatment of newborn jaundice, Method From 2001 to 2006yr, intervention treatments were performed for the pregnant women whose ABO lgG anti-A （B） was no less than 1：64 or antibody was positive except for ABO. Entire course monitor and intervention treatment of newborn jaundice were performed for 6 267 the newborn infant. Results Entire course monitors were accepted by 6 267 newborn that total accounted for 99.82%; 1 412 cases were diagnosed as indirect bilirubin ascension of hyperbili- rubinemia, and 1 409 cases were charged over to the pediatrics department to be intervened and 895 cases were diagnosed within 48 hours, accounting for 97.37% and 63,52% respectively, There was significant difference compared with full term newborn group and ABO hemolysis newborn group in total serum bilirubin value with post-treatment result （P〈0.01）, There was no significant difference between hyperbilirubinemia group （excluding high-risk newborn） and normal newborn group in intelligence test, Conclusion The entire course management monitor and interventing treatment of new born jaundice could make the management of pregnant woman and newborn finer.