慢性阻塞性肺疾病全身炎症反应研究进展

Development on systemic inflammation of chronic obstructive pulmonary disease

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）不仅表现为肺部炎症，而且伴随全身性炎症反应。COPD的全身性炎症反应包括全身性氧化应激、外周血炎症细胞活化和前炎细胞因子产生等，可以参与机体一系列的病理生理过程。认识COPD全身性炎症反应，可能对患者病情的评估和治疗有重要意义。

Chronic obstructive pulmonary disease （COPD） is characterized by not only chronic inflammation in the pulmonary tissue, but also systemic inflammation. These changes detected in systemic inflammation includes evidence of oxidative stress, the presence of activated inflammation cells and increased plasma levels of proinflammation cytokines. They participate in a series of pathphysiological processes of organism. A better understanding of the effects underlying these systemic inflammation can facilitate the clinical assessment as well as the treatment of the patients.