表皮生长因子受体与气道黏液高分泌

Epidermal growth factor receptor and airway mucus hypersecretion

黏液高分泌是慢性气道炎症性疾病的重要病理特征之一，也是患者病情加剧恶化的重要因素。表皮生长因子受体（EGFR）是一种受体酪氨酸激酶（RTK），在气道黏液高分泌的信号转导通路中居于中心地位，各种炎性介质、病原微生物及其产物、活性氧等可通过多种信号转导通路活化EGFR，活化相关转录因子引起黏蛋白5AC基因表达上凋。明确EGFR上下游信号通路势必对慢性气道炎症性疾病的防治提供指导。

Mucus hypersecretion is a prominent feature in patients with chronic inflammatory airway diseases and an important factor which causes the exacerbation of these diseases. Epidermal growth factor receptor （EGFR） is a receptor tyrosine kinase and a crossing point of many cell signaling pathways in airway mucus hypersecretion. EGFR can be activated by a wide variety of stimuli through multiple signaling pathways including various inflammatory mediators, pathogens and its products, reactive oxygen. EGFR pathway can upregulate the expression of mucin SAC by activating many transcription factors. To study EGFR can provide new insights to the therapies of the pulmonary inflammatory diseases.