妊娠期肝内胆汁淤积症患者影响围生儿预后高危因素分析

Risk Factors of Fetal Prognosis Mala in Patients with Intrahepatic Cholestasis of Pregnancy

目的探讨妊娠期肝内胆汁淤积症(ICP)患者影响围生儿预后的高危因素。方法对2004年1月～2006年12月我院146例ICP孕妇皮肤瘙痒、血清胆汁酸、肝功能指标及围生儿预后进行回顾性分析。结果ICP患者皮肤瘙痒明显,血清胆汁酸、胆红素和转氨酶升高程度与发生羊水粪染、胎儿窘迫、产后出血、早产儿的比例相关。结论皮肤瘙痒明显,血清胆汁酸和肝功能指标升高是ICP孕妇围生儿预后不良的高危因素,必须高度重视,适时改善妊娠结局。

Objective To explore the risk factors of fetal prognosis mala in patients with intrahepatic cholestasis of pregnancy. Methods 146 pregnant women with ICP were investigated between January 2004 and December 2006. Itch of skin, serum bile acids and liver function index were obtained from patients records. Results Predictors of fetal prognosis mala included itch of skin, serum bile acids and ALT. There was an positive association between the degrees of itch of skin, serum bile acids , ALT and the rates of meconium - contaminated amniotic fluid, fetal distress, postpartum hemorrhage, proportion of premature infant. Conclusion Fetal prognosis mala is common in patients with ICP. It is associated with both the degree of itch of skin and the levels of serum bile acidS, ALT.