摘要
盐酸氟西汀是目前临床广泛使用的一种新型抗抑郁药物,市场销售的盐酸氟西汀是以外消旋体形式存在的。研究表明,盐酸氟西汀的一对对映体具有不同的药效及半衰期,对其对映体的不对称合成研究显得十分重要,针对近年来盐酸氟西汀的不对称合成方法研究的进展进行论述。
Fluoxetine hydrochloride is a potent and highly selective inhibitor of neutral serotonin-reuptake and is one of the most important drugs for the treatment of psychiatric disorders and metabolic problems. Due to its market value and the different pharmacological activities displayed by analogues of fluoxetine, several synthetic methods, including the enantioselective synthesis of both enantiomers, have been reported. Progress in enantioselective synthetic methods of fluoxetine hydrochloride were reviewed in this paper.
出处
《化学工业与工程》
CAS
2008年第3期251-258,共8页
Chemical Industry and Engineering
基金
国家自然科学基金资助项目(No.30576094)
关键词
抗抑郁药物
盐酸氟西汀
不对称合成
antidepressants
fluoxetine hydrochloride
enantioselective synthesis
