摘要
以水杨酰胺为原料,经乙酰化、溴代、氨解、缩合和还原5步反应制得拉贝洛尔。反应条件温和,工艺稳定,其质量符合国家药品标准。
Labetalol was prepared from salicylic amide by five steps： acetylation, bromo-substitution, aminodegradation, condensation and reduction. This approach was stable and easy to control.
出处
《化学工业与工程》
CAS
2008年第3期276-278,共3页
Chemical Industry and Engineering
关键词
拉贝洛尔
高血压
合成
Labetalol
hypertension
synthesis
