Zn^(2+)对实验性糖尿病大鼠的降血糖作用

EFFECT OF Zn 2+ ADMINISTRATION ON HYPERGLYCEMIA IN EXPERIMENTAL DIABETIC RATS

使用四氧嘧啶诱发的糖尿病大鼠观察了Ｚｎ２＋的降血糖效应。腹腔注射Ｚｎ２＋（ＺｎＣｌ２，１２０ｍｇ／ｋｇ）后１小时血糖即呈明显下降，２小时后下降速率加快，３小时内即可基本恢复正常血糖水平。口服Ｚｎ２＋（ＺｎＣｌ２，２４０ｍｇ／ｋｇ）后２小时内血糖呈明显下降，但不能降至正常水平，２小时后血糖下降不再显著。Ｚｎ２＋降血糖的详细机制尚不十分明了，可能与其可促进葡萄糖向脂肪细胞转运并加速其转变成脂肪有关。

Administration of ZnCl 2 by intraperitoneal or oral may normalize blood glucose levels in alloxan-induced diabetic rats.After intraperitoneal ZnCl 2 injection (120ng/kg),the blood glucose level cut down obviously in an hour and returned to normal levels in three hours.The blood glucose levels dropped markedly,but not return to normal levels in two hours by oral ZnCl 2(240mg/kg).