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室间隔缺损并心力衰竭患儿氨基末端脑钠肽的变化 被引量:1

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摘要 检测室间隔缺损(VSD)并心力衰竭(HF)患儿的氨基末端脑钠肽(NT-proBNP)和肌钙蛋白T(CTnT)水平,同时行超声心动图检测左室射血分数(LVEF)及肺动脉压力,并与健康儿童作对照。结果HF组NT-proBNP显著高于对照组(P<0.05),并与HF临床严重程度、CTnT呈显著正相关(P<均0.01),与LVEF无关(P>0.05);肺动脉高压可引起NT-proBNP升高;NT-proBNP≥244.82 fmol/m l者心脏事件发生率为53.84%,CTnT阳性者心脏事件发生率为71.42%。认为VSD并HF患儿NT-proBNP显著高于正常,并与HF的临床严重程度、CTnT呈正相关,是诊断小儿HF、判断心肌损伤的特异性生化指标;联合检测NT-proBNP和CTnT有助于诊断和预测小儿HF的预后。
出处 《山东医药》 CAS 北大核心 2008年第13期49-50,共2页 Shandong Medical Journal
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