妊娠期外阴、阴道假丝酵母菌感染对围生结局影响的对照研究

Study for the influence of vulvovaginal candidiasis on the pregnancy outcomes

目的对妊娠晚期合并外阴、阴道假丝酵母菌感染（VVC）分类并探讨其对围生结局的影响。方法对300例妊娠晚期妇女阴道分泌物进行真菌培养，筛查VVC患者，按t临床特征评分分为轻度、重度VVC，随访至产后42d，记录妊娠结局及新生儿感染情况。结果妊娠晚期真菌感染率34％。重度VVC组在胎膜早破、胎盘胎膜粘连、早产、产时会阴延裂、产后切口裂开、新生儿感染方面明显增多，与非VVC组比较差异有统计学意义（均P〈0.01）；在产褥感染方面无统计学意义（P〉0．05）。结论妊娠期重度VVC，对母婴造成不良影响，孕前、孕期应积极预防治疗。

Objective To investigate the incidence of vulvovaginal candidiasis （VVC） in the third trimester,and the effect on the of perinatal outcome. Methods Vaginal discharge samples of 300 gravida were examined and cultured for fungus. According to the clinical feature, the patients were divided into slight VVC group and heavy VVC group. The termination of pregnancy and perinatal outcome were recorded 42 days after delivery. Results The incidence of VVC was 34%. There was significantly higher prevalence of premature rupture of membrane（PROM） , afterbirth adherence, premature labor, break of perinaeum when intrapartum, disruption of wound after intrapartum and infection of newborn in the group of heavy VVC, with significant difference as compared with non-VVC group （ P 〈 0.01 ） but with no difference in puerperal infection （ P 〉 0.05 ）. Conclusion Heavy VVC is disadvantageous to the mothers and their babies in gravida, and the therapy of VVC in pregnant women should be conducted actively before and after delivery.