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腹腔注射造影剂小鼠MRI增强扫描的可行性 被引量:1

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摘要 目的评价腹腔注射造影剂小鼠MRI增强扫描的可行性。方法采用Philips Achieva1.5T超导磁共振成像仪和内径47mm的显微镜线圈对15只小鼠体部行TSE-T1WI扫描,平扫后腹腔注射钆贝葡胺后4、8、12、16、20min行连续增强扫描。测量平扫和增强扫描各时相肝脏、右侧肾脏、右侧颈后部肌肉的信号强度,并计算强化率。结果增强扫描各时相肝脏、右侧肾脏、右侧颈后部肌肉的信号强度均明显地高于平扫(P<0.01),但扫描各时相各组织间强化率均无统计学差异(P>0.05)。结论腹腔注射钆贝葡胺后4minT1WI小鼠组织、器官信号增高,且强化持续时间较长,表明腹腔注射是一种简便易行的MRI增强扫描方法。
出处 《江苏医药》 CAS CSCD 北大核心 2008年第5期513-515,共3页 Jiangsu Medical Journal
基金 苏州市社会发展基金(SZD0614) 苏州大学青年教师基金(Q3123557)
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  • 1Lee SM, Lee SH, Kang HY, et al. Assessment of musculoskeletal infection in rats to determine usefulness of SPIO-enhanced MRI[J]. AJR, 2007,189 (3): 542-548.
  • 2Su MY, Taylor JA, Villarreal LP, et al. Prediction of gene therapy-induced tumor size changes by the vascularity changes measured using dynamic contrast-enhanced MRI[J]. Magn Reson Imaging, 2000,18(3) : 311-317.
  • 3Berkowitz BA, Roberts R, Luan H, et al. Dynamic contrastenhanced MRI measurements of passive permeability through blood retinal barrier in diabetic rats[J]. IOVS, 2004,45 (7) : 2391-2398.
  • 4Cha S, Johnson G, Wadghiri YZ, et al. Dynamic,contrastenhanced perfusion MRI in mouse gliomas: correlation with histopathology[J]. Magn Reson Med, 2003,49 (5) : 848-855.
  • 5Grimm J, Potthast A, Wunder A, et al. Magnetic Resonance imaging of the pancreas and pancreatic tumors in a mouse orthotopic model of human cancer[J]. Int J Cancer, 2003,106 (5) :806-811.
  • 6Yeung SC, She M,Yang H, et al. Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model[J]. JCEM, 2007,92 (8) : 2902-2909.
  • 7Shukla S, Maclerman GT, Marengo SR, et al. Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model [J]. Prostate, 2005,64 (3) : 224-239.
  • 8Aguilar S, Corominas JM, Malats N, et al. Tissue plasminogen activator in murine exocrine pancreas cancer:selective expression in ductal tumors and contribution to cancer progression [J]. Am J Pathol,2004,165(4) :1129-1139.
  • 9Sun Y,Schmidt NO, Schmidt K,et al.Perfusion MRI of U87 brain tumors in a mouse model[J]. Magn Reson Med,2004,51 (5) :893-899.

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