复方丹参注射液联合维生素E佐治新生儿寒冷损伤综合征临床观察

Clinical observation of administration of compound salvia injection combined with vitamin E in neonatus with cold injury syndrome

目的探讨复方丹参注射液与维生素E联合应用治疗新生儿寒冷损伤综合征的效果。方法将52例寒冷损伤综合征患儿分为2组,对照组22例采用常规治疗,观察组30例在常规治疗基础上加用复方丹参注射液1-2 mL·kg^-1·d^-1及维生素E局部外用,观察患儿体温恢复时间、一般情况好转时间、硬肿消退时间及治疗效果。结果观察组患儿体温恢复时间、一般情况好转时间及硬肿消退时间较对照组明显缩短（P〈0.05）,观察组总有效率（96.6%）明显高于对照组（86.4%,P〈0.05）。结论复方丹参注射液联合维生素E局部外用治疗新生儿寒冷损伤综合征效果好,可缩短体温恢复时间和硬肿消退时间。

Objective To observe the effects of administration of compound salvia injection with vitamin E on neonatal cold injure syndrome. Methods Fifty two child patients were randomly divided into observation group and control group. Twenty two child patients in the control group were given conventional therapy;based on the conventional therapy, thirty cases in the observation group were given 1 -2 mL·kg^-1·d^-1 compound salvia injection and Vitamin E as reginal external use. The recovery time of body temperature, the improvement time of general state, the extinction time of scleredema, and therapeutic efficacy of both groups were observed. Results The recovery time of body temperature, the improvement time of general state and the average extinction time of scleredema in the observation group were obviously shortened to those in the control group（ P 〈 0.05 ）. The total effective rate of the observation group （96. 6% ） was higher than that of the control group （ 86.4% ,Χ^2 = 7.37, P 〈 0.05 ）. Conclusion The therapy of administration of compound saliva injection with Vitamin E can shorten the recovery time of body temperature and the extinction time of scleredema. It can cure neonatal cold injury syndrome effectively and safely.