唑来膦酸治疗恶性肿瘤骨转移性疼痛85例的临床观察

A Clinical Study of Zoledronic Acid in Pain Relief for Patients with Metastatic Bone Tumors

目的观察唑来膦酸治疗恶性肿瘤骨转移性疼痛的疗效及不良反应。方法85例恶性肿瘤骨转移疼痛的患者每次予唑来膦酸4mg,加入100ml生理盐水中静脉滴注,滴注时间大于15min,每4周1次,至少连续2次。结果止疼效果:完全缓解15例(17.6%),明显缓解24例(28.2%),中度缓解30例(35.3%),轻度缓解16例(18.8%),中位起效缓解时间为第3天,平均缓解时间28天。主要不良反应为发热,消化道反应,短暂性疼痛加剧,肌酐水平轻度升高,反应轻,无需特殊处理。结论唑来膦酸治疗恶性肿瘤骨转移性疼痛镇痛效果较好,持续时间较长,不良反应轻,患者能耐受。

Objective To evaluate the efficacy and toxicities of Zoledronic acid in pain relief for patients with metastatic bone tumors. Methods 85 paticents with metastatic bone tumors were treated with 4 milligram of Zoledronic acid. The treatment was repeated every four weeks. Treatment efficacy and toxicities were evaluated after at least 2 cycles. Results Complete pain re- lief was achieved in 17.6% （15/18） patients, and significant pain relief was achieved in 28.2% （24/85） patients. 35.3% （30/85） patients had moderate pain relief, and 18, 8% （16/85） patients had mild pain relief. The median time to begin the pain relief was 3 days, and the mean time of pain relief was 28days. The main adverse effects included febricity, gastrointestinal reactions, temporal aggravation of the bone pain and slight increase of creatinine level. Conclusion Zoledronic acid treatment is effective in the treatment of metastatic bone tumors with lasting pain relief and minimum toxicities.