摘要
目的介绍释放一氧化氮型阿司匹林(NO-ASA)在防治肿瘤方面的最新进展。方法查阅国内外文献资料进行整理和归纳。结果NO-ASA防治肿瘤作用靶点较广泛,对人结肠癌和其它癌细胞株有抑制作用,还可以作为抗癌药顺铂的辅助治疗药。结论NO-ASA是一种有希望作为抗结肠癌和其它癌的防治药。
出处
《西北药学杂志》
CAS
2008年第3期184-186,共3页
Northwest Pharmaceutical Journal
参考文献15
-
1陈传意,周剑涛,蒙丽华.释放一氧化氮型非甾体抗炎药[J].西北药学杂志,2006,21(3):138-140. 被引量：4
-
2万英,陈传意,周剑涛,邱雄泉.释放一氧化氮型他汀类药的血管保护作用[J].西北药学杂志,2006,21(4):190-191. 被引量：3
-
3Bratasz A,Weir NM, Parinandi NL, et al. Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin[J]. PNAS, 2006,103(10) : 3914-3919.
-
4Carini M, Aldini G, Orioli M,et al. In vitro metabolism of a nitroderivative of acetylsalicylic acid (NCX4016) by rat liver: LC and LC-MS studies[J]. J Pharm Biomed Anal, 2002, 29(6): 1061-1071.
-
5Carini M ,Aldini G, Stefani R. , et al. Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirinl in vitro and in vivo studies in the rat by ESR spectroscopy [J]. J Pharm Biomed Anal, 2001, 26(4) : 509-518.
-
6Kashfi K, Ryan Y, Qiao LL, et al. Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect[J]. J Pharmacol Exp Ther, 2002, 303(3) : 1273-1282.
-
7Turchi JJ. Nitric oxide and cisplatin resistance: NO easy answers[J]. PNAS, 2006, 103(12): 4337-4338.
-
8Gao JJ, Liu XP, Rigas B. Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress[J]. PNAS, 2005, 102 (47) : 17207-17212.
-
9Williams JL,Nath N , Chen J, et al. Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention[J]. Cancer Res, 2003, 63 (22) : 7613-7618.
-
10Ouyang N, Williams JL, Tsioulias GJ, et al. Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model[J]. Cancer Res, 2006, 66(8):4503-4511.
二级参考文献31
-
1Momi S,Emerson M,Paul W,et al.Prevention of pulmonary thromboembolism by NCX-4016,a nitric oxide-releasing aspirin[J].Eur J Pharmacol,2000,397 (1):177-185.
-
2Napoli C,Aldini G,Wallace JL,et al.Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis[J].Proc Natl Acad Sci USA,2002,99 (3):1689-1694.
-
3Maffia P,Ianaro A,Sorrentino R,et al.Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis[J].Arterioscler Thromb Vasc Biol,2002,22(2):263-267.
-
4Ignarro LJ,Buga GM,Wei LH,et al.Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation[J].Proc Natl Acad Sci USA,2001,98(7):4202-4208.
-
5Kashfi K,Ryann Y,Qiao LL,et al.Nitric oxide-donating nonsteroidal a nti-inflammatory drugs inhibit the growth of various cultured human cancer cells:evidence of a tissue type-independent effect[J].J Pharmacol Exp Ther,2002,303 (3):1273-1282.
-
6Armour KJ,Vant Hof RJ,Armour KE,et al.Inhibition of bone resorption in vitro and prevention of ovariectomyinduced bone loss in vivo by flurbiprofen nitroxybutylester(HCT1026)[J].Arthritis Rheum,2001,44(9):2185-2192.
-
7Wainwright CL,Miller AM,Work LM,et al.NCX4016(NO-aspirin) reduces infarct size and suppresses arrythmias following myocardial ischaemia/reperfusion in pigs[J].Br J Pharmacol,2002,135(8):1882-1888.
-
8Al-Swayeh OA,Futter LE,Clifford RH,et al.Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity[J].Br J Pharmacol,2000,130 (7):1453-1456.
-
9Muscara MN,Mcknight W,Lovren F,et al.Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney,one-clip rats[J].Am J Physiol,2000,279(2):H528-H535.
-
10Jantzen PT,Connor KE,Dicarlo G,et al.Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice[J].J Neurosci,2002,15 (6):2246-2254.
共引文献5
-
1钟守琳,周剑涛.释放一氧化氮型阿司匹林的抗癌作用机制[J].生命的化学,2008,28(1):20-22. 被引量：1
-
2程继文,蒙清贵,陆浩源,王植柔,白先忠.一氧化氮释放型阿司匹林对荷瘤小鼠前列腺癌血管形成的抑制作用[J].第二军医大学学报,2010,31(5):504-507. 被引量：8
-
3黄孝银,王东,孙海钰,张赵凯,沈欣.一氧化氮供体型与传统型NSAID对小鼠骨折骨愈合的影响分析[J].中国当代医药,2012,19(12):18-19.
-
4吴洋,郭雨泽.浅谈偏头痛合理用药[J].黑龙江科技信息,2013(34):52-52.
-
5牛犇,吕莹.他汀类药与抗血小板药物联用对急性脑梗死血脂及血液流变学的影响[J].中国继续医学教育,2016,8(9):128-129. 被引量：5
同被引文献7
-
1王艳,王立,王战云,计红萍.阿司匹林对顺铂抗卵巢癌作用增敏效应的体外实验研究[J].中国现代医学杂志,2006,16(18):2748-2750. 被引量：3
-
2Kim KY,Seol JY,Jeon GA.The combined treatment of aspirin and radia-tion induces apoptosis by the regulation of bcl-2 and caspase-3 in human cervical cancer cel(lJ).Cancer Lett,2003;189(2):157-66.
-
3Setiawan VW,Matsuno RK,Lurie G.Use of nonsteroidal anti-inflammato-ry drugs and risk of ovarian and endometrial cancer:the Multiethnic Co-hor(tJ).Cancer Epidemiol Biomarkers Prev,2012;21(9):1441-9.
-
4Sutcliffe S,Grubblii RL,Platz EA.Non-steroidal anti-inflammatory drug use and the risk of benign prostatic hyperplasia-related outcomes and nocturia in the prostate,lung,colorectal,and ovarian cancer screening tri-a(lJ).BJU Int,2012;110(7):1050-9.
-
5Bondong S,Kiefel H,Hielscher T.Prognostic significance of L1CAM in o-varian cancer and its role in constitutive NF-κB activation(J).Ann On-col,2012;23(7):1795-802.
-
6郭向梅(综述),刘风玲(审校).环氧化酶-2及其抑制剂与卵巢癌相关性的研究[J].实用肿瘤学杂志,2011,25(1):91-95. 被引量：3
-
7徐晓辉,申爱荣.COX-2在上皮性卵巢肿瘤的表达及塞来昔布对卵巢癌A2780细胞株凋亡的影响[J].中国肿瘤外科杂志,2011,3(2):102-105. 被引量：1
-
1肖希龙,周宗灿,等.一氧化氮对大鼠肝细胞信号系统和代谢酶活性影响的[J].癌变．畸变．突变,1997,9(6):383-384.
-
2钟守琳,周剑涛.释放一氧化氮型阿司匹林的抗癌作用机制[J].生命的化学,2008,28(1):20-22. 被引量：1
-
3王泓.罗氏公司中止Avastin临床试验的患者招募[J].中华医学信息导报,2006,21(5):18-18.
-
4赵延斌.我院抗肿瘤药物的应用现状和发展趋势分析[J].中国药业,2010,19(6):49-50. 被引量：2
-
5房相娟.抗肿瘤药物用药分析[J].中国保健营养（下半月）,2013,0(1):300-300.
-
6刘平羽,李莉.2004—2007年我院抗肿瘤药用药分析[J].中国药业,2009,18(15):42-43. 被引量：2
-
7孙惠娟,孙艳,胡坤,刘茹.我院2001～2005年抗肿瘤药利用分析[J].中国药房,2007,18(5):326-328. 被引量：10
-
8胡婉素,刘帆.抗肿瘤药物不良反应97例分析[J].现代实用医学,2011,23(3):334-335. 被引量：4
-
9活性氧和活性氮[J].德国临床用药,2001,4(3):44-44.
-
10徐贵丽,彭显平,牟冰,杨艳,尹玉琴.格拉司琼与顺铂氟尿嘧啶配伍的相互作用研究[J].解放军药学学报,2001,17(6):340-341.
