摘要
RNA沉默是一种依赖核酸序列特异性的RNA降解过程,是动物、植物抵抗病毒等外源核酸的一种保守防御机制。而针对寄主的这种防御机制,许多病毒演化出RNA沉默抑制子以克服这种防御反应。本文综述了几种动物、植物病毒抑制子的结构和作用方式,讨论了病毒抑制子之间的交叉抑制功能,病毒运动和沉默抑制子之间的关系,病毒RNA和亚病毒寄生物通过沉默抑制子而进行的自我保护原理,抑制子对于miRNA(microRNA)途径的影响以及病毒抑制子在生物技术方面的应用。
RNA silencing is a conservative eukaryotic defense mechanism, which is attached to the degradation of exogenous nucleic acid via specific sequences interactions. Viruses have evolved suppressor proteins that help them successfully infect their hosts to counteract it. We perform a survey of structures and effects of some viral suppressors from several plant and animal viruses. We discuss the ability of cross-kingdom suppression of suppressors, the link between movement and silencing suppression, . the self-protection principles of viral RNA and subviral parasites by silencing suppressors, the effects of viral silencing suppressors on the microRNA pathway, and the biotechnological applications of silencing suppressors.
出处
《山东科学》
CAS
2008年第2期21-26,38,共7页
Shandong Science
基金
国家自然科学基金项目(30270875)
山东省中青年科学家科研奖励基金(2005BS02007)
