麻黄汤不同配伍对大鼠脑内Glu/GABA比值的影响

Effects of different compatibiliies of MahuangTang on the ratio of Glu and GABA in rats

目的:研究麻黄汤不同配伍对大鼠额叶皮层中谷氨酸/γ-氨基丁酸(Glu/GABA)比值的影响。方法:采用HPLC法测定氨基酸类神经递质的量。结果:桂枝、杏仁、甘草均显著降低了大鼠额叶皮层中Glu/GABA比值(P=0.021,0.007,0.028),且桂枝与甘草(P=0.014)、杏仁与甘草(P=0.009)呈显著的一级交互作用。结论:麻黄汤不同配伍对大鼠额叶皮层中Glu/GABA比值的影响呈规律性变化。

Objective：To study effects of the different compatibility of MahuangTang（MHT） on the ratio of Glu and GABA in the prefrontal cortex of the rats. Methods： Use HPLC/UV to determine the content of amino acids. Results： Ramulus Cinnamomi , Semen Armeniacae Arnarum and Radix Glycyrrhizae had significantly reduced the relative value of Glu and GABA（P = 0. 021,0. 007,0. 028）. The two-way interaction of Radix Glycyrrhizae and another factors had significant effect on the ratio of Glu/GABA（ P = 0. 014,0. 009）. Conclusion： The different compatibilities of MHT had regular influence on the ratio of Glu/GABA.