供肾体积及功能与术后移植肾功能的关系研究

Impact of donor kidney volume and renal function on post - transplant graft function

目的探讨供肾体积及功能与术后移植肾功能的关系。方法对53例亲属活体肾移植供、受者术前的供肾体积及功能与受者术后平稳期移植肾功能的关系进行统计分析研究。结果术前供肾体积与术后移植肾功能密切相关（r=0．539，P〈0．01），其中供肾体积大于110cm^3者术后移植肾功能显著优于体积小者（81．19＋16．5 vs 66．97＋12．72ml／min，P〈0．01）；术前供肾功能与术后移植肾功能存在一定的相关性（r=0．363，P＜0．01）。结论术前供肾体积大小与功能状况是影响术后移植肾远期功能的重要因素。当患者有多个供肾来源时．应优先选择供肾体积较大及功能良好者。从而提高移植肾的远期存活率。

Objectives To investigate the impact of donor kidney volume and renal function on post-transplant graft function. Methods The correlations of the donor kidney volume, the renal function and the mean SCr 13.2 months after kidney transplantation were studied in 53 living kidney donor - recipient pairs. Results The donor kidney volume had an obvious impact on the mean SCr 13.2 months after kidney transplantation（ r =0. 539, p 〈0. 01 ）. A donor kidney volume greater than 110 cm^3 was independently associate with better GFR at the mean 13.2 months post - transplant when compared to recipients of lower donor kidney volume（81.19 ＋ 16.5 vs 66. 97 ＋ 12.72 ml/min, p 〈 0.01 ） ; the donor kidney ideal function was positively correlated with the mean SCr 13.2 months post- operation（ r=0. 363, p 〈0.01 ）. Conclusions The donor kidney volume and the renal function are important factors that influence long - term allograft function after kidney transplantation. It is suggested that larger and good - functional kidneys should be preferred when selecting from otherwise similar living donors.