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细胞周期调控因子Cdc25的研究进展 被引量：7

Research advances in regulator Cdc25 in cell cycle
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摘要 综述了Cdc25(cell division cyclin 25)磷酸酶的结构、在细胞周期调控中的作用及调控机制以及在致癌转化中的作用。概述了Cdc25磷酸酶在多种人类癌症中的过表达。最后,叙述了近年来关于使用小分子抑制剂抑制Cdc25磷酸酶的研究进展,展望了开发治癌药物的前景。 The structure,roles and mechanism of Cdc25 phosphatases in control of cell cycle were reviewed. The roles of Cdc25 phosphatases in oncogenic transformation and Cdc25 phosphatases overexpression in many cancers were summarized. Lastly, recent efforts in the design of Cdc25 specific lnhibitors were presented, and the prospects for development of the drugs for treatment of cancers were discussed.
作者 张晖 陈秋生
机构地区 南京农业大学动物医学院
出处 《中国兽医科学》 CAS CSCD 北大核心 2008年第5期447-450,共4页 Chinese Veterinary Science
基金 国家自然科学基金项目(30671513)
关键词 Cdc25磷酸酶 调控 过表达 癌症 抑制剂 Cdc2 5 phosphatases control overexpression cancer inhibitor
分类号 Q25 [生物学—细胞生物学]
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参考文献17

  • 1KRISTJANSDOTTIR K, RUDOLPH J. Cdc25 phosphatases and cancer[J]. Chem Biol, 2004,11 (8) : 1043-1051.
  • 2邹向阳,李连宏.细胞周期调控与肿瘤[J].国际遗传学杂志,2006,29(1):70-73. 被引量：74
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二级参考文献8

共引文献91

同被引文献105

  • 1邹向阳,李连宏.细胞周期调控与肿瘤[J].国际遗传学杂志,2006,29(1):70-73. 被引量：74
  • 2马云彤,齐浩.CDC25在细胞周期运行和细胞周期检验点应答中的作用和调控机制[J].西安文理学院学报（自然科学版）,2006,9(4):11-17. 被引量：6
  • 3朱虹,缪泽鸿,丁健.ATM、ATR和DNA损伤介导的细胞周期阻滞[J].生命科学,2007,19(2):139-148. 被引量：20
  • 4Chen CY et al. Kotomolide A arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and the initiation of mitochondrial system in human non-small cell lung cancer A549 cells. Food Chem Toxicol, 2008, 46: 2476- 2484.
  • 5Wang Z et al. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. BMC Cancer, 2010, 10:233.
  • 6Wang X et al. HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma. Nucleic Acids Res, 2006, 34(Database issue): D607-D612.
  • 7Nilsson I et al. Cell cycle regulation by the Cdc25 phosphatase family. Prog Cell Cycle Res, 2000, 4:107-114.
  • 8Boutros R et al. The when and where of Cdc25 phosphatases. Curr Opin Cell Biol, 2006, 18:185-191.
  • 9Senju M et al. Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines. J Cancer Res Clin Oncol, 2006, 132:150-158.
  • 10Gall L et al. Unexpected nuclear localization of Cdc25C in bovine oocytes, early embryos, and nuclear-transferred embryos. Reproduction, 2008, 135:431-438.

引证文献7

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中国兽医科学
2008年 第5期

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