涎腺肿瘤微血管密度及血管内皮生长因子表达的意义

Significance of microvessel density and vascular endothelial growth factor expression in salivary tumors

目的研究血管内皮生长因子（VEGF）与微血管密度（MVD）在涎腺肿瘤中的表达，探讨其临床病理意义。方法采用SP免疫组化染色方法检测42例涎腺肿瘤中VEGF与MVD的表达，采用SPSS软件统计行分析。结果VEGF在涎腺肿瘤中的表达明显高于正常涎腺组织（P〈0．05）；MVD在涎腺恶性肿瘤与多形性腺瘤中的分布有显著性差异（P〈0．005）；但MVD在多形性腺瘤中的分布与正常涎腺组织无显著性差异（P〉0．05）；VEGF在涎腺肿瘤中的表达与MVD无显著相关性。结论在涎腺肿瘤中，VEGF有较高水平表达；MVD在多形性腺瘤中的表达不明显，但在涎腺良恶性肿瘤中分布有显著性差异；VEGF的表达与MVD无显著相关性。

Objective To examine the expression of microvessel density （MVD） and vascular endothelial growth factor （VEGF） in salivary tumors and to explore the relationship among the expression of VEGF , the MVD and the biological behavior of the salivary tumors. Methods The expressions of MVD and VEGF on 42 salivary tumors patients and controls were detected by immunohistochemistry. The data was disposed by SPSS software. Results The expression of VEGF in salivary tumors was.higher than that in normal controls（P 〈 0. 05）. The MVD of salivary gland carcinoma was significant higher than that in polymorphic adenoma （PA） ,P 〈 0. 005. No significant difference was seen between the MVD in salivary tumors and that in controls （ P 〉 0. 05 ）. No correlation was found between the expression of VEGF and MVD in salivary tumors. Conclusion There was high level of VEGF expression in salivary tumors. The level of MVD expression is very low in PA, The MVD of salivary gland carcinoma was significant higher than that in PA . It is no correlation between the expression of VEGF and MVD in salivary tumors.