还原性谷胱甘肽佐治脑出血脑水肿的临床研究

The treatment of cerebral hemorrhage with reduced glutathione

目的探讨还原性谷胱甘肽辅助治疗脑出血脑水肿的作用。方法收集脑出血患者76例，分为2组，还原性谷胱甘肽治疗组38例，对照组38例。治疗前后进行神经功能评分，测量脑水肿体积。结果①入院后第7、14天神经功能评分增加值（分）差异有统计学意义，治疗组（分别为13．7±4．4、22．9±3．6）高于对照组（分别为11．3±3．9、18．0±4．2）。②第72小时、第7天脑水肿体积（cm^3）：治疗组（分别为19．3±4．8、19．2±4．3）低于对照组（分别为25．1±5．41、25．1±5．37），差异有统计学意义。结论还原性谷胱甘肽能够抑制脑水肿的形成，提高脑出血患者神经功能评分。．

Objective To discuss the mechanism of reduced glutathione in treatment of cerebral hemorrhage. Methods Totally 78 patients were divided into two groups：reduced glutathione treating group （38 cases） and control group （38 cases）. The patient＇s neurologic function was marked according to the European Standards of Grading For Cerebral Attacking . The volumes of edema were observedby CT in 72 hours ,7 days after their attacks. Results The therapeutic effects in treating group （13.7 ± 4. 4,22. 9 ± 3.6, respectively ） were significantly higher than those in control group（ 11.3 ± 3.9,18.0 ± 4. 2, respectively）. The volumes of edema （ cm^3 ） in treating group （ 19. 3 ± 4. 8,19.2 ± 4. 3, respectively） were significantly less than those in the control group （25.1 ± 5.41,21.5 ± 5.37, respectively）. Couclusions Reduced glutathione might inhibit the formation of cerebral edema and improve the neurologic function marks after attacks.