高血压病人血脂和脂蛋白水平变化与肾损害的关系

Relationship between Changes of Lipid and Lipopreotein Levels and Renal Lesion in Hypertensive Patients

目的探讨高血压病人血脂、脂蛋白水平变化与肾损害的关系。方法将106例高血压患者分为高血压未发生肾损害组（n=44）、高血压早期肾损害组（n=40）、高血压肾损害组（n=22），以104例血压正常者作为对照组，检测血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1及B（apoA1、apoB）、脂蛋白（a）[LP（a）]，进行比较分析。结果高血压病人血清TC、TG、HDL—C、LDL-C、apoB、LP（a）水平明显高于正常对照组，差异有显著性意义（P均〈O．01），HDL-C水平明显高于正常对照组p〈0．05）。TC、LDL—C、apoB水平随高血压早期肾损害的加重呈现升高的趋势，高血压肾损害组病人血清LP（a）水平及异常率明显高于高血压早期肾损害组和未发生肾损害组，差异有显著性意义（p〈0．05，p〈0．01），其余各指标异常率均无显著性意义。结论高血压病人存在着明显的脂质异常，高血压肾损害与脂质代谢紊乱相关联，肾损害加重脂质代谢紊乱。

Objective To study the relationship between the change of lipid and lioporotein level and renal lesion in hypertensive patients. Method 106 patients with hypertension were divided into there goups： hypertension without renal lesion group （n=44）, hypertension with early renal lesion group （n=40） and hypertension with renal lesion group （n=22）,104 subjects without hypertension served as normal controls. The serum levels of cholesterol（TC）, triglyceride （TG）, high density lipoprotein cholestein cholestein （HDL-C）, low density lipoprotein Al（apoA1）, apolipoprotein B（apoB）and lipoprotein （a）[Lp（a）]were measured and compared.. Results The serum levels of TC, TG, LDL-C, apoB and Lp（a） in hytertensive patients The level of HDL-C in hypertension groups was obviously lower than that in normal controls （P〈0.05）. An increasing tendency shew in the levels of serum TC , LDL-Cand apoB along with the aggravation of the renal lesion in hypertensive patrents .The serum level and abnormal rate of Lp（a） inhyper tension with ienal lesion group were obviously higher than those in groups of hypertension with early renal lesion and without renal lesion , and the differences were significant. Conclusions Abnormal lipid is found in hypertensive patients. Renal lesion in hypertension is correlated to metabboliam disorder of lipid, and can aggravate metabolism disorder of lipid .