结膜乳头切除加丝裂霉素C治疗春季角结膜炎

Intraoperative mitomycin-c use after the excision papillae in vernal keratoconjunctivitis

目的观察铺路石样乳头切除加术中应用MMC治疗春季角结膜炎（VKC）的疗效和安全性。方法选取10例（20眼）上睑结膜有铺路石样乳头的VKC，行乳头切除加术中应用0．4mg／mL MMC2分钟。观察术后患者的主觉症状和体征变化。随访2～12月。结果所有患者的主觉症状和体征均显著改善，4眼上睑结膜面见细小散在乳头复发。未见MMC应用的并发症发生。结论对有铺路石样乳头的VKC，行乳头切除加术中应用0.4mg／mL MMC是安全、简便、有效的治疗方法。

Objective To observe the efficacy and safety of excision of cobblestone-like papillae combined with 0.4 mg/ml mitomycin-C （MMC）use in patients with vernal keratoconjunctivits. Methods 10 cases of vernal keratoconjunctivits enrolled in this study. All patients had cobblestone-like papillae on the upper tarsal conjunctiva. Papillary excision combined with intraoperative use of 0.4 mg/ml MMC for 2 minutes to the upper palpebral conjunctiva. Postoperative observation included clinical symptoms and signs. Follow-up ranged from 2 to 12 months. Results The clinical symp- toms and signs of all patients got significanly better. Some thin Papillae regrowth was observed in 4 of 20 eyes（20% ）after surgery. No adverse effects of MMC use were observed. Conclusions Excision of cobblestone-like papillae combined with MMC use on the upper palpebral conjunctiva in patients with VKC was safe and effactive.