甘露糖结合凝集素的研究进展

Mannose-binding lectin: From bench to personalized medicine

甘露糖结合凝集素(MBL)是先天性免疫系统的重要成分之一,在免疫防御中发挥多重作用。MBL基因多态性与多种疾病易感性、严重程度以及预后密切相关。在免疫系统尚未成熟的儿童,或同时存在原发或继发免疫缺陷的患者,低表达MBL基因型与感染性疾病、自身免疫性疾病的相关性尤其显著。因此,MBL的检测和替代治疗即将应用于个体化医疗。作者就MBL在疾病和健康中的作用、检测方法学的进展及MBL相关的治疗作一综述。

Mannose-binding lectin （MBL） is a key component of the innate immune system that plays a pluripotent role in natural defense. MBL genetic variants are associated with increased susceptibility to and the severity and prognosis of various diseases. The association between low MBL-producing allelic variants and disease risk and/or severity is particularly strong in infectious and autoimmune diseases. Enhanced risk for disease by low MBL producers is particularly the case for children and immunocompromised patients, especially when primary and secondary immune deficiencies coexist. Therefore the use of MBL testing and replacement therapy has reached the threshold of personalized medicine. The author presents a review of the role of MBL in health and diseases, the advances in MBL testing methodology and MBL related therapies.