摘要
Ezrin是埃兹蛋白/根蛋白/膜突蛋白(ERM)家族成员之一,是一种膜细胞骨架连接蛋白。近年来的研究发现,Ezrin在多种恶性肿瘤细胞中异常表达,提示其在肿瘤的浸润、转移机制中发挥着重要作用。Ezrin通过改变肿瘤细胞运动、调节细胞间黏附、参与肿瘤细胞内信号转导、抑制细胞凋亡和调理吞噬细胞的吞噬功能等方面,影响恶性肿瘤的转移。
Ezrin, a member of the ERM（EzrirL/Radixin/Moesin）protein family, fuctions as a molecular linker between the cytoskeleton and the plasma membrane. Recently, it has been found to be expressed abnormally in many malignant tumors, which indicats that it plays indicative of an important role in tumor infiltration and metastasis. Ezrin influences tumor metastasis in many ways, aspects including altering tumor cell movement, regulating cell-cell adhesion, participating in signal transduction in tumor cells,inhibiting cell apoptosis and regulating the function of phagocytes.
出处
《医学研究生学报》
CAS
2008年第5期542-546,共5页
Journal of Medical Postgraduates
基金
南京军区南京总医院科研基金资助项目(批准号:nz06006)
