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microRNAs：心血管疾病重要的调控因子 被引量：3

microRNAs: important regulators in cardiovascular diseases
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摘要 微RNA(microRNA,miRNA)是一类内源性19-25个核苷酸大小的非编码RNA分子,在进化中具有高度保守性,并且能够通过碱基匹配原则识别靶基因3'非翻译区的靶位点,从而抑制编码蛋白靶基因的翻译或(和)降解靶基因。目前的研究表明,miRNA在生物体发育、心血管疾病以及肿瘤发生等过程中起重要作用。本文对miRNA在心血管系统生理病理中的作用做一综述。 microRNAs are a class of endogenous 19-25 nucleotides non-coding RNAs. They are highly conserved and specify translational repression or/and mRNA cleavage through the recognition of complementary sequences in the 3＇-UTRs of target mRNAs of protein-coding genes. Researches indicated that miRNAs play pivotal roles in development of organisms, cardiovascular diseases and tumor, et al. This review focus on the mechanism of miRNAs on the physiopathology of cardiovascular system.
作者 朱霓 秦永文 荆清
机构地区 上海长海医院心内科 中国科学院上海生命科学研究院健康科学研究所
出处 《生命科学》 CSCD 2008年第2期218-221,共4页 Chinese Bulletin of Life Sciences
基金 “973”项目2005CB7246022007CB947002) 国家自然科学基金面上项目(30570397,30670437,30770457) 浦江人才计划(05PJ14105)
关键词 MICRORNA 血管生成 心肌肥厚 心力衰竭 心律失常 microRNA angiogenesis cardiac hypertrophy heart failure arrhythmia
分类号 Q522 [生物学—生物化学] R541 [医药卫生—心血管疾病]
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参考文献27

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同被引文献26

  • 1Eric J, Topoi MD. The genomic basis of myocardial infarction [J]. J Am Coll Cardiol,2005 ;46 (8) : 1456-65.
  • 2Yoon KA,Yoon H,Park S,et al. The prognostic impact of microRNA se- quence polymorphisms on recurrence of patients with completely resected non - small cell lung cancer [J]. J Thorac Cardiovasc Surg,2012 ; 144 (4) : 794-807.
  • 3Boni V, Zarate R, Viila JC, et al. Role of primary miRNA polymorphic va- riants in metastatic colon cancer patients treated with 5-fluorouracil and iriontecan[ J]. Pharmacogenomics J ,2011 ; 11 (6) :429-36.
  • 4Yang HS, Colin PD, Ye YQ, et al. Evaluation of genetic variants in mi- croRNA-related genes and risk of bladder cancer[ J]. Cancer Res,2008; 68:2530-7.
  • 5Claque J, Lippman SM, Yang H, et al. Genetic variation in mieroRNA genes and risk of oral premalignant lesions [ J ]. Mol Carcinog, 2010 ; 49 (2) :183-9.
  • 6Christine Esau,Scott Davis,Susan F. Murray,Xing Xian Yu,Sanjay K. Pandey,Michael Pear,Lynnetta Watts,Sheri L. Booten,Mark Graham,Robert McKay,Amuthakannan Subramaniam,Stephanie Propp,Bridget A. Lollo,Susan Freier,C. Frank Bennett,Sanjay Bhanot,Brett P. Monia.miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting[J]. Cell Metabolism . 2006 (2)
  • 7Liu, Xi,Sempere, Lorenzo F,Ouyang, Haoxu,Memoli, Vincent A,Andrew, Angeline S,Luo, Yue,Demidenko, Eugene,Korc, Murray,Shi, Wei,Preis, Meir,Dragnev, Konstantin H,Li, Hua,DiRenzo, James,Bak, Mads,Freemantle, Sarah J,Kauppinen, Sakari,Dmitrovsky, Ethan.MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors[J]. Journal of Clinical Investigation . 2010 (4)
  • 8Kazuo Motoyama,Hiroshi Inoue,Yasushi Takatsuno,Fumiaki Tanaka,Koshi Mimori,Hiroyuki Uetake,Kenichi Sugihara,Masaki Mori.Over- and under-expressed microRNAs in human colorectal cancer[J]. International Journal of Oncology . 2009 (4)
  • 9Hammond SM.An overview of microRNAs. Advanced Drug Delivery Reviews . 2015
  • 10Justin W. Caravaggio,Mirela Hasu,Robin MacLaren,Mohamed Thabet,Joshua E. Raizman,John P. Veinot,Yves L. Marcel,Ross W. Milne,Stewart C. Whitman.??Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice(J)Cardiovascular Pathology . 2013

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生命科学
2008年 第2期

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