高压氧联合甲钴胺治疗糖尿病周围神经病变的疗效

Effects of therapy of hyperbaric oxygen combined with mecobalamin on diabetic peripheral neuropathy

目的评价高压氧联合甲钴胺对糖尿病周围神经病变的疗效，探讨治疗糖尿病周围神经病变的有效方法。方法378例糖尿病周围神经病变患者分为2组。治疗组198例，予高压氧联合甲钴胺治疗，高压氧疗法采用大型空气加压舱，治疗压力为0．2MPa（2．0ATA），每日1次；甲钴胺500μg，肌肉注射，每日1次。对照组180例，单独使用甲钴胺500μg，肌肉注射，每日1次。2组患者疗程均为4周。结果治疗组显效率、总有效率分别为40．9％和100％，明显高于对照组的17．3％及53．3％，2组间差异有统计学意义（P〈0．01）；治疗组神经传导速度及血流动力学改善均明显高于对照组（P〈0．01）。结论高压氧联合甲钴胺对糖尿病周围神经病变的治疗效果显著，总有效率为100％，可作为糖尿病周围神经病变的常规治疗方法。

Objective To study effects of hyperbaric oxygen combined with mecobalamine on diabetic peripheral neuropathy （DPN） and explore effective therapeutic way to DPN. Methods Three hundred and seventy-eight patients were divided into two groups. The treatment group （198 cases ） were treated with hyperbaric oxygen（HBO） and mecobalamin （0.2 MPa, 500 μg mecobalamin i. m. ,once a day）. The control group（ 180 cases） were only treated with 500μg mecobalamin i. m. , once a day. Courses of treatment in two groups both were four weeks. Results The effective rate and overall efficacy rate of treatment group were 40.9% and 100%, respectively. They were significantly higher than those of control group （ 17. 3% and 53.3% ） （P 〈 0.01 ）. At the same time, there were obvious differences in nerve conduction velocity and dynamics of blood flow between two groups （ P 〈 0.01 ）. Conclusions HBO combined with mecobalamin has therapeutic effect on DPN, which may be regared as a conventional therapy.