摘要
1名8l岁女性患者，因患肝癌肺转移，口服索拉菲尼400mg，2次／d，服药4周双手、足及双侧乳头出现刺痛并伴有脱皮，6周出现恶心，食欲不振，大便次数增多。尽管索拉菲尼剂量改为400mg／d和对症治疗，症状仍无好转。服药至20周时食欲极差，恶心明显，腹泻10～20次／d，为稀水样便，体重下降7kg，停止服用索拉菲尼。停药2个月后恶心症状缓解，食欲改善，大便次数减少为3～4次／d，体重未再下降。
An 81-year-old woman with pulmonaly metastasis of liver cancer received oral sorafenib 400 mg twice daily. On week 4, the patient experienced a prickling on her hands, feet, and nipples accompanied with desquamation. On week 6, she presented with nausea, anorexia and an increase in number of stools. Despite a decrease in her sorafenib dosage to 400 mg once daily and symptomatic treatment, the symptoms still did not improve. On week 20, severe anorexia, marked nausea, diarrhea with l0 - 20 times watery stools daily and weight loss of 7 kg occurred in the patient. Sorafenib was discontinued. Two months later, her nausea resolved; her appetite improved ; her daily number of stools was reduced to 2 - 3, and her weight loss did not occur again.
出处
《药物不良反应杂志》
2008年第2期136-137,共2页
Adverse Drug Reactions Journal
关键词
索拉菲尼
刺痛
腹泻
sorafenib
prickling
diarrhea
