摘要
1例37岁施行胆囊切除术的男性患者,在术后给予克林霉素3g,2次/d静脉滴注。次日患者出现全身性疼痛,尿呈褐色潜血。实验室检查显示:游离血红蛋白196mg/L,网织红细胞0.20,尿铁血黄素(+),TBil83.32μmol/L,IBil60.2μmol/L,诊断为急性药物性溶血性贫血。停用克林霉素,给予碱性液体水化及还原型谷胱甘肽治疗,1周后患者各项指标逐渐正常。
A 37-year-old man underwent gallbladder resection was administered IV clindamycin 3 g twice daily after surgery. The following day, the patient developed generalized pain, brown urine with occult blood. Laboratory testing showed the following values： free hemoglobin 196 mg/L, reticulocyta count 0.20, urine hemosiderin （ ＋ ） , TBil 83.32 μmol/L, and IBil 60.2 μmol/L. Acute drug-induced hemolytic anemia was diagnosed. Clindamycin was discontinued, and he was hydrated by infusion of alkaline fluid and given reduced glutathione. One week later, his indices normalised gradually.
出处
《药物不良反应杂志》
2008年第2期142-143,共2页
Adverse Drug Reactions Journal
