摘要
目的:研究环氧化酶-2(Cox-2)及血管内皮细胞生长因子(VEGF)在乳腺癌发生发展中的相关作用。方法:应用免疫组织化学法检测128例乳腺癌组织中Cox-2、VEGF及ER和PR的表达。结果:Cox-2及VEGF在乳腺癌组织中的表达有明显正相关(rs=0.852,P<0.05),并且在激素受体阴性组患者的表达高于阳性组患者,(χ2cox-2=12.40,χ2VEGF=8.85,P<0.01)。结论:Cox-2及VEGF在乳腺癌的表达具有提示预后的作用,其相应抑制剂有一定的临床应用前景。
OBJECTIVE： To investigate the expressions of cyclooxygenase-2 （ Cox-2 ） and vascular endothelial growth factor （VEGF） in human breast cancer and their correlation. METHODS： Expressions of Cox-2 and VEGF including ER and PR in 128 cases of human breast cancer were detected with immunohistochemistry. RESULTS： The expressions of Cox-2 and VEGF in breast cancer had a close relation,r1 = 0. 852, P〈0. 05. The positive rates of Cox-2 and VEGF were significantly higher in positive hormane receptor tumor than those in negative ones （χcox-2^2 = 12.40, χVEGF^2 = 8.85 , P〈0.01）. CONCLUSIONS： The expressions of Cox-2 and VEGF may play an important role of prognosis of breast cancer. Selective Cox-2 and VEGF inhihitors may he useful in the chemoprevention and therapy of human breast cancer.
出处
《中华肿瘤防治杂志》
CAS
2008年第10期762-764,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
乳腺肿瘤
血管内皮生长因子A
前列腺素内过氧化物合酶
激素受体
breast neoplasms
vascular endothelial growth factor A
prostaglandin-endoperoxide synthase
hormane receptor
