FFA、oxLDL-C与2型糖尿病视网膜病变的相关性研究

The association of type 2 diabetic retinopathy with FFA and oxLDL-C

目的探讨游离脂肪酸(FFA)、氧化低密度脂蛋白(oxLDL-C)与2型糖尿病视网膜病变(DR)的相关性。方法2型糖尿病(T2DM)组108例,分为单纯糖尿病(DM)组40例和糖尿病视网膜病变(DR)组68例,与42例健康对照(NC)组比较。铜显色法测定血清FFA、酶联免疫吸附法测定ox-LDL-C,对视网膜相关危险因素行logistic回归分析。结果DR组与DM组、NC组比较;血清FFA、oxLDL-C明显升高,(P<0.05)。T2DM组为整体,有无视网膜病变为因变量,FFA、oxLDL-C及其他危险因素为自变量,进行logistic回归分析。最后LDL-C、FFA-C、oxLDL-C和病程进入回归方程。结论FFA、oxLDL-C是DR的重要危险因素。

Objective To study the relationship of free fatty acids and oxLDL-C with diabetic retinopathy （DR）. Methods The 108 type 2 diabetes cases with （n=68） and without （n=40） DR were enrolled,and compared with 42 health control. FFA was determined by copper chromogenic method, oxLDL- C was determined by ELISA with kits provided, The correlation of risk factors with retinopathy was analyzed by logistic regression analysis, Results FFA and oxLDL-C levels were higher in DR group than in groups of DM and control. Logistic regression analysis showed that as the independent risk factors for DR pathogenesis, LDL-C, FFA,oxLDL-C and course of disease entered into regression equation. Conclusions FFA and oxLDL-C are the important risk factors for DR.