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DNA修复基因XRCC1多态性与肺癌易感性研究进展 被引量:4

Progress in Polymorphism of XRCC1 and Susceptibility to Lung Cancer
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摘要 X线修复交叉互补基因1(XRCC1)是一种重要的DNA修复基因,参与DNA单链断裂和碱基损伤修复,其编码的蛋白质在碱基修复过程中是不可缺少的。该基因的多态性会导致相应的氨基酸改变,从而影响DNA修复,可能引起肿瘤的易感性。XRCC1基因多态性与吸烟交互作用对肺癌易感性的关系仍然存在争论,其相关性需进一步深入研究。
作者 李红 毛伟敏
机构地区 浙江省肿瘤医院
出处 《中国肿瘤》 CAS 2008年第5期386-389,共4页 China Cancer
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