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分化抑制因子3的表达调控机理及其功能 被引量:3

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摘要 分化抑制因子3(inhibitor of differentiation 3,Id3)属于螺旋-环-螺旋(helix-loop-helix,HLH)转录因子家族成员之一,该分子参与细胞周期调控过程,在细胞生长与发育、机体的生理及病理过程中发挥重要调控作用。其表达和功能涉及许多复杂的调控机制。
出处 《生命的化学》 CAS CSCD 北大核心 2008年第4期134-136,共3页 Chemistry of Life
基金 江苏省"六大人才高峰"基金资助课题(No.050203D)资助
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参考文献17

  • 1Ruzinova MB et al. Trends Cell Biol, 2003, 13(8): 410-418.
  • 2Yokota Yet al. Cell Physiol, 2002, 190(1): 21-28.
  • 3李晓军,秦浚川.细胞分化抑制因子(Id)研究进展[J].生物化学与生物物理进展,2004,31(10):865-869. 被引量:29
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  • 10Chen X et al. J Mol Cell Cardiol, 2006, 41(1): 26-33.

二级参考文献28

  • 1Singh J, Murata K, Itahana Y, et al. Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex.Oneogene, 2002, 21 (12): 1812 ~ 1822
  • 2Ling M T, Wang X, Ouyang X S, et al. Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth. Oncogene, 2002, 21 (55): 8498 -8505
  • 3Ling M T, Wang X, Ouyang X S, et al. Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells. Oncogene, 2003, 22 (29): 4498 - 4508
  • 4Benezra R, Davis R L, Lockshon D, et al. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell, 1990, 61 (1):49-59
  • 5Norton J D. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci, 2000, 113 (Pt.22): 3897 - 3905
  • 6Ruzinova M B, Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell Biol, 2003, 13 (8): 410 -418
  • 7Yokota Y, Mori S. Role of Id family proteins in growth control. J Cell Physiol, 2002, 190 (1): 21 -28
  • 8Ohtani N, Zebedee Z, Huot T J, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.Nature, 2001, 409 (6823): 1067 - 1070
  • 9Yates P R, Atherton G T, Deed R W, et al. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J, 1999, 18 (4): 968 -976
  • 10Kee B L, Rivera R R, Murre C. Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF β. Nat Immunol,2001,2 (3):242-247

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