间充质干细胞表达趋化因子及受体的相关生物学功能

Biological Function of Chemokines and Chemokine Receptors from Mesenchymal Stem Cells

间充质干细胞(mesenchymal stemcells,MSCs)是一群存在于骨髓间质和其他组织间质的干细胞,表达CD34和CD133。近来研究发现,存在于骨髓的间充质干细胞除了能支持造血,向骨细胞、软骨细胞和脂肪细胞进行多向分化外,其分泌的趋化因子及其相关受体在MSCs的信号转导、维持内环境的稳定、损伤修复、免疫调节、支持造血等功能中也发挥了关键性的作用。

Mesenchymal stem cells （MSCs） are stem cells that exist in bone marrow interstitial or other matrix which can express CD34 and CD133. Bone-marrow derived MSCs not only have the ability of haematogenesis, differentiation into osteoblasts, adipocytes and chondrocytes, recent study reveals that the chemokines they secreted and MSCs-related receptors also play an important role in signal conduction, homeostasis, injury repair and immunity regulation.