人源性多肽Dermcidin的特性与功能

Characteristic and Function of the Human-derived Peptide Dermcidin

人源性多肽dermcidin(DCD)是最近从人汗液中分离的一种天然活性多肽。它在汗腺中组成性表达并分泌到体表的汗液中,作为抗菌肽参与调节皮肤菌群结构。以前在人类神经细胞中发现的一种存活促进肽以及人体内与一种鼠恶病质因子同源的多肽均被证实为DCD衍生肽。最新研究发现dermcidin基因在多种类型肿瘤及人胎盘组织中表达,表明DCD可能作为多功能的活性多肽在肿瘤发生及人体天然免疫系统、神经系统疾病、妊娠相关疾病的病理生理过程中发挥作用。

The human-derived peptide dermcidin （DCD）, a natural active peptide isolated from human sweat recently, plays a role in the regulation of human skin flora as an antimicrobial peptide. DCD was specifically and constitutively expressed in the sweat glands, and then was secreted into the sweat and transported to the epidermal surface. It has been confirmed that a survival-promoting peptide and a human homologous of a mouse cachexia factor reported previously are both DCD-derivative peptides. Besides, dermcidin expression has been identified in multiple human tumor types and in gestational tissue, indicating that DCD may acts as a multifunctional active peptide which might be involved in tumorigenesis and the pathophysiology of pregnancy-related disorders, as well as human innate immune system disorders and neuronal diseases.