应用hMG/HCG超促排卵治疗不孕症50例

Treatment of infertility by ovulation induction with hMG/HCG in 50 cases

为了研究国产人类绝经期促性腹激素（hMG）配伍绒促性素（HCG）的超促排卵作用，50例病人90个周期接受了hMG／HCG超排卵治疗。自月经周期第5天开始肌注hMG75u，用B超、宫颈粘液评分及血雌激素、孕激素监测排卵，当优势卵泡平均直径≥18mm时，停用hMG，肌注HCG5000u促排卵。结果显示：hMG／HCG促排卵治疗排卵率为91.0％，妊娠率为24.0％，卵巢过度刺激综合征（OHSS）发生率为44.0％、OHSS发生时妊娠率显著升高达45．4％，尤以多囊卵巢综合征明显。结论：hMG／HCG超排卵治疗不孕症有较好的疗效，国产hMG治疗效果基本与国外产品相近。

Objective: To assess the impact of ovulation induced by hMG/HCG in women with infertility.Method:Fifty women were treated by hMG/HCG in 90 menstrual cycles in 1992- 1995. hMG 75u was in-jected since the fifth day of menstruation. When the mean diameter of the largest oocyte is more than18mm, HCG 500u was given to trigger ovulation. B-ultrasonic examination, cervical mucus Insler score,blood estrogen and progesterone level were estimated to monitor ovulation. Results:The incidence of ovula-tion was 91 %. 12 women got pregnant among 50 patients (24% ). Ovarian hyperstimulation syndrome(OHSS) occurred in 22 women (44%) with a high rate of pregnancy (45. 4% ). Conclusion: Ovulation byhMG/HCG treatment is a good method for women with infertility. OHSS could not be prevented totally,but we must pay attention to it. The number of oocytes and serum estradiol(E,) Ievel could be used for theprediction of OHSS.