90年代上海地区痢疾杆菌菌群分布及耐药性变迁

VARIATION OF DISTRIBUTION AND RESISTANCE OF SHIGELLA STRAIN IN 199OS

研究90年代痢疾杆菌菌群分布及耐药性变迁。1989年至1995年对本院门诊及住院的腹泻病人进行粪便细菌培养及药敏试验。结果：7a中从13836份粪便标本中检出痢疾志贺氏菌共1814株，总检出率1311％，其中弗氏菌（B群）占优势82.47％，宋代菌（D群）17.25％。每年以8～11月份检出率最高。药敏试验结果显示痢疾杆菌对丁胺卡那、头孢三嗪及头孢他啶皆敏感，庆大霉素及呋哺妥因较敏感，对氟喹诺酮类敏感率仅80％左右，对氨苄青霉素、四环素、SMZco及化力新明显耐药。结论：自1990年始上海地区弗氏菌逐渐超过宋氏菌而成为细菌性痢疾的主要流行菌群，痢疾杆菌的耐药性有所增加，提示应合理用药。

PURPOSE To analyze the variation of flora distribution and drag resistance of Shigella Strains in 199Os.METHODS Stools of outpatients and hospitalized patients with diarrhea from 1989 to l995 were cultured,and antibiotic sensitivity was tested for shigella strain.RESULTS Totally 1 8 1 4 strains were isolated from 1 8 3 6 3 stools samples (l 3. 1 l % ) with S. Fiexneri 82. 47 % and S. sonnei l7. 25 %. The antibiotic sensitivity test showed that Amikarcin, Cefatriaxone and Ceftazidime remained high sensitive rate, Gentamicin and Furantoin intermediate sensitive, whereas Ampicillin,Tetracycline, SMZco and Unasyn highly resistant. The sensitive rate to Fluoroquinolones was round 8O%.CONCLUSIONS Since 1990, the incidence of S. Flexneri gradually exceeded that of S. sonnei in Shanghai district and the resistance rate of Shigella strains relatively increased indicating that antimicrobials should be carefully and reasonably used.