中药芪蒿合剂对裸鼠移植人体鼻咽癌的抑制作用

Growth inhibition effects of the compound decoction of astragalus and artemisia on human nasopharyngeal cancer xenografted in nude mice

目的：根据我们过去的实验，特设本实验以了解此合剂体内抗肿瘤作用。方法：本实验用裸鼠移植人鼻咽癌（ＳＵＮＴ－１）检测中药芪蒿合剂Ⅰ、Ⅱ、Ⅲ的抗肿瘤作用。结果：灌服合剂Ⅰ，在相当于１２．５ｇ生药·ｋｇ－１剂量下，抑制率为３５．６％，在３３．５ｇ生药·ｋｇ－１剂量下，抑瘤率为３６．４％和５２．５％；灌服合剂Ⅱ在２５．３ｇ生药·ｋｇ－１剂量下，抑瘤率为５０．５％；灌服合剂Ⅲ在２０ｇ生药·ｋｇ－１剂量下，抑制率为３４％。结论：芪蒿合剂Ⅰ、Ⅱ、Ⅲ均有抗裸鼠移植人鼻咽癌作用。

Purpose: In order to inverstigate the antitumor effect of Chinese herbal compound decoctions of Astragalus and Artemisia were examined in nude mice xenografted with human nasopharyngeal cancer (SUNT-1). Method: The antitumor activity of compound decoction Ⅰ、Ⅱ、Ⅲ was studied, inhibition rates were 35.6～52.5% under the doses of compound decoction Ⅰ 12.5 g and 33.5 g crude drng/kg-1·d-1; Results: The inhibition rate was 50.5% under the dose of compound decoction Ⅱ 25.3 g crude drug/kg-1·d-1; The inhibition rate was 34% under the dose of compound decoction Ⅲ 20 g crude drug·kg-1·d-1. Conclusion: The experiment results showed that the compound decoctions of Astragalus and artemisia possessed antitumor activities in vivo.