纹状体和杏仁核多巴胺及其代谢产物含量与雌激素的关系

RELATIONSHIP BETWEEN THE CONTENTS OF DOPAMINE AND ITS METABOLITES FROM STRIATAL AND AMYGDALOID TISSUE AND SEX

①目的研究纹状体（Ｓｔｒ）和杏仁核（Ａｍｙ）中多巴胺（ＤＡ）及其代谢产物含量与雌激素的关系。②方法用高效液相色谱－电化学检测法测定了雌鼠和去卵巢（ＯＶＸ）大鼠Ｓｔｒ和Ａｍｙ中ＤＡ及其代谢产物的含量。③结果ＯＶＸ组Ｓｔｒ中ＤＡ，３，４－二羟苯乙酸和高香草酸（ＨＶＡ）含量高于雌鼠组，两组相比差异有极显著性（ｔ＝４．７８，６．６１，Ｐ均＜０．００１；ｔ＝３．２５，Ｐ＜０．０１）；ＯＶＸ组Ａｍｙ中ＤＡ，ＨＶＡ含量高于雌鼠组，两组相比差异有极显著性（ｔ＝３．４３，５．１１，Ｐ均＜０．０１）。④结论ＯＶＸ大鼠Ｓｔｒ和Ａｍｙ中ＤＡ及其代谢产物高于正常雌鼠组，提示雌激素可能参与调控Ｓｔｒ和Ａｍｙ的ＤＡ代谢。

Objective To study the relationship between the content of dopamine(DA) and its metabolites from rat striatal and amygdaloid tissue and sex. Methods Highperformance liquid chromatography with electrochemical detection was used to measure DA and its metabolites content from female, male and ovariectomized(OVX) female rats. Results The contents of DA, 3,4dihydroxyphenylacetic acid(DOPAC) and homovanillic acid(HVA) in the striatum in OVX group were significantly higher than those in the female groups(t=4.78, 6.61, P<0.001; t=3.25, P<0.01). The contents of DA, HVA in the amygdala in OVX group were higher than those in other two groups, of which HVA content in OVX group was significantly higher (t=3.43,5.11, P<0.01).  Conclusion The results of this study suggest that female hormone, estrogen and/or progesterone may take part in the modulation of DA metabolism of striatum and amygdala. 