摘要
①目的探讨中央杏仁核内神经降压素(NT)的胃粘膜保护作用与前列腺素(PGS)的关系。②方法双侧中央杏仁核内注射微量神经降压素,肌肉注射前列腺素合成阻断剂,放射免疫分析测定胃粘膜内前列腺素E2(PGE2)的含量。③结果肌肉分别注射消炎痛和阿斯匹林均能拮抗NT的胃粘膜保护作用(t=5.216~12.335,P均<0.01),双侧中央杏仁核内注射保护剂量的NT能翻转水浸加束缚(CWR)引起的胃粘膜PGE2含量的降低(t=2.261~3.415,P均<0.05)。
Objective To study the protective effect of neurotensin(NT) in the central amygdala(CEA) on gastric mucosa and its relationship with prostaglandins( PGS) Methods NT was injected into the CEA,prostaglandin synthesis inhibitors were injected into the skeleton muscle of rats, the amounts of gastric mucosal prostaglandin E2 ( PGE2) were measured by radioimmunoassay. Results Intramuscular injection of indomethacin or aspirin totally blocked the protective effect of NT (t=5. 216 ̄12. 335, P< 0. 01) , bilateral microinjections of NT into the CEA of cold water restraint(CWR) rats totally reverse the decrease of the gastric mucosal PGE2 level(t=2.261~3.415, P<0. 05). Conclusion The results suggest that PGS may mediate the protective effect of NT in the CEA on gastric mucosa.
出处
《青岛医学院学报》
1997年第4期307-309,共3页
Acta Academiae Medicinae Qingdao Universitatis
基金
山东省卫省厅科技发展基金