神经降压素对胃粘膜的保护作用及与前列腺素关系

THE PROTECTIVE EFFECT OF NEUROTENSIN ON GASTRIC MUCOSA AND ITS RELATIONSHIP WITH PROSTAGLANDINS

①目的探讨中央杏仁核内神经降压素（ＮＴ）的胃粘膜保护作用与前列腺素（ＰＧＳ）的关系。②方法双侧中央杏仁核内注射微量神经降压素，肌肉注射前列腺素合成阻断剂，放射免疫分析测定胃粘膜内前列腺素Ｅ２（ＰＧＥ２）的含量。③结果肌肉分别注射消炎痛和阿斯匹林均能拮抗ＮＴ的胃粘膜保护作用（ｔ＝５．２１６～１２．３３５，Ｐ均＜０．０１），双侧中央杏仁核内注射保护剂量的ＮＴ能翻转水浸加束缚（ＣＷＲ）引起的胃粘膜ＰＧＥ２含量的降低（ｔ＝２．２６１～３．４１５，Ｐ均＜０．０５）。

Objective To study the protective effect of neurotensin(NT) in the central amygdala(CEA) on gastric mucosa and its relationship with prostaglandins( PGS) Methods NT was injected into the CEA,prostaglandin synthesis inhibitors were injected into the skeleton muscle of rats, the amounts of gastric mucosal prostaglandin E2 ( PGE2) were measured by radioimmunoassay. Results Intramuscular injection of indomethacin or aspirin totally blocked the protective effect of NT (t=5. 216￣12. 335, P< 0. 01) , bilateral microinjections of NT into the CEA of cold water restraint(CWR) rats totally reverse the decrease of the gastric mucosal PGE2 level(t=2.261～3.415, P<0. 05). Conclusion The results suggest that PGS may mediate the protective effect of NT in the CEA on gastric mucosa. 