聚对二氧环己酮网制备及重建犬胸壁缺损的研究

Preparation of a polydioxanone mesh as chest wall prosthesis

目的通过生物材料的选择和制备，研制新型可降解人工胸壁修复材料，并通过动物实验探讨其用于胸壁重建的可行性。方法采用聚对二氧环己酮（PDO）纤维编织成网状结构人工胸壁，应用于犬胸壁缺损重建动物模型，8、16、24周处死实验犬，观察人工材料降解变化、材料与组织结合界面、胸壁再生情况。结果PDO网可以重建胸壁稳定性，并在24周内逐步降解吸收，由机体再生组织完全取代。结论PDO网具备适宜的可降解特性，作为胸壁重建材料，可获得有效胸壁稳定，具有良好临床应用前景。

Objective To investigate the feasibility of a novel biodegradable surgical mesh as chest wall prosthesis. Methods Biodegradable chest wall prosthesis made of polydioxanone monofilament was explored in a canine model. The degradation process of prothesis,interface between tissue and bioma- terial and chest wall regeneration were observed. Results The polydioxanone mesh was reabsorbed and replaced by autogeneous tissue within 24 weeks and achieved perfect chest wall stabilization. Conclusion The polydioxanone mesh investigated here shows favorable biodegradation properties and provide good chest wall stabilization.