俞募穴埋线治疗卵巢早衰疗效观察

Clinical observation on catgut implantation at Shu-and Mu-acupoints for treatment of premature ovarian failure

目的:观察肝脾肾之俞募穴埋线治疗卵巢早衰的临床疗效。方法:将132例卵巢早衰患者随机分成埋线组和药物组,每组各66例。埋线组给予肝脾肾之俞募穴埋线治疗;药物组采用激素替代疗法,即口服戊酸雌二醇(补佳乐)2 mg,每日1次,连服20天,10天后加服安宫黄体酮4 mg,每日2次,连服10天,平均用药6个月。观察2组疗效及血清促卵泡激素(FSH)和雌二醇(E2)变化。结果:2组治疗后血清FSH和E2均有显著改善(P<0.01),且埋线组血清E2提高较药物组显著(P<0.01)。埋线组痊愈率为84.9%,总有效率为97.0%;药物组分别为31.8%、84.8%。埋线组痊愈率优于药物组(P<0.05)。随访10个月,埋线组疗效可维持。结论:肝脾肾之俞募穴埋线治疗卵巢早衰疗效好,无任何毒副作用,值得临床推广应用。

Objective To observe clinical therapeutic effect of catgut implantation at Shu- and Mu-acupoints of liver, spleen and kidney on premature ovarian failure. Methods One hundred and thirty-two cases of premature ovarian failure were randomly divided into a catgut implantation group and a medication group, 66 cases in each group. The catgut implantation group were treated by catgut implantation at Shu- and Mu-acupoints of liver, spleen and kidney, and the medication group were treated with oral administration of Estradiol Valerate 2 mg, qd, for 20 days, and 10 days later, Medroxyprogesterone Acetate 4 mg was added, b, i. d, for 10 days, averaging 6 months of medication, The therapeutic effects and changes of serum follicle-stimulating hormone （FSH） and estradiol （Ez） were observed in the two groups, Results After treatment, serum FSH and E2 significantly improved in the two groups （P〈0. 01）, with the serum E2 in the catgut implantation group increased more significantly than that in the medication group （P〈0.01）, The cured rate and the total effective rate were 84, 9% and 97.0% in the catgut implantation group and 31, 8% and 84.8% in the medication group, the cured rate in the catgut implantation group being better than that in the medication group （P〈0.05）, Ten month later, the therapeutic effect in the catgut implantation group was kept. Conclusion Catgut implantation at Shu- and Mu-acupoints of liver, spleen and kidney has a good therapeutic effect on premature ovarian failure with no side effect,