草珊瑚中香豆素化学成分研究

Studies on chemical constituents of Sarcandra glabra

目的：研究草珊瑚中的具有抗菌活性的化学成分。方法：对草珊瑚干燥全草乙醇提取物中具有抗菌活性的氯仿部分和醋酸乙酯部分进行柱色谱分离，根据各种波谱技术和理化性质研究确定各活性化合物的结构。结果：首次从草珊瑚干燥全草中分离得到6种具有抗菌活性的香豆精类化学成分，分别为4，4′-双异嗪皮啶（4，4′-biisofraxidin，1），秦皮乙素（esculetin，2），秦皮素（fraxetin，3），滨蒿内酯（scoparone，4），异嗪皮啶（isofraxidin，5），东莨菪内酯（scopoletin，6）。结论：化合物1为1个新的天然产物，化合物2—4为首次从金粟兰科植物中分离得到，首次测定了6种香豆精类化学成分的抗菌活性，一些化合物具有进一步研究开发成为抑制口腔细菌的天然药用植物制剂的潜力。

Objective： To study antibacterial chemical constituents of Sarcandra glabra. Method： The constituents of the chloroform and EtOAc-soluble portions of the EtOH exlxact from the whole plant of S. glabra, which posses the antibacterial activities, were isolated and purified with column chromatography. The compounds were identified by physical and spectroscopic techniques. Re- sult： Six compounds were isolated and identified as 4, 4＇-biisofraxidin （ 1 ）, esculetin （ 2 ） , fraxetin （ 3 ）, scoparone （ 4 ）, isofraxidin （5）, scopoletin（6）, respectively. Conclusion： Compound 1 is a novel natural product. Compounds 2-4 were isolated from the plants of Chloranthaceae for the first time. The antibacterial activities of these six compounds were tested for the first time. Some compounds may have potential for future study and development as plant-derived oral antibacterial agents.