苏木心材中一个新黄酮类化合物

A new flavonoid from heartwood of Caesalpinia sappan

目的:从苏木Caesalpinia sappan中寻找新的活性成分。方法:用溶剂萃取及硅胶正相色谱进行活性成分的分离纯化,根据理化性质、光谱数据进行结构鉴定。结果:从苏木95%乙醇提取物中分离得到了9个化合物:3,8-dihydroxy-4,10-dimethoxy-7-oxo-[2]benzopyrano[4,3-b][1]benzopyran-7-(5H)-one(1),3-deoxysappanchal-cone(2),sappanchalcone(3),3-deoxysappanone B(4),鼠李素(rhamnetin,5),原苏木素C(protosappanin C,6),3,7-di-hydroxy-chroman-4-one(7),己二酸二甲酯(8),胡萝卜苷(daucosterin,9)。结论:化合物1为新化合物,化合物7,8为首次从该植物中分离得到。药理筛选结果表明,化合物3对多种癌细胞株具有一定的抑制活性。

Objective： To seek for new active components from Caesalpinia sappan. Method： The chemical constituents were isolated and identified by means of chromatographic and spectroscopic technologies methods. Result： Nine compounds were isolated, and their structures were identified as 3, 8-dihydroxy-4, 10-dimethoxy-7-oxo- [ 2 ] benzopyrano [ 4,3-b ] benzopyran （ 1 ）, 3-deoxysap- panchalcone （2）, sappanchalcone （3）, 3-deoxysappanone B （4）, rhamnetin （5）, protosappanin C （6）, 3, 7-dihydroxy-chroman-4- one （7） , dimethyl adipate （8） , daucosterin （9）. Conclusion： Compound 1 was a new compound, and compounds 7, 8 were isolated from this plant for the first time.