长期服用青木香或冠心苏合丸对大鼠肝、肾功能的影响

Hepatic and renal injury induced by Radix Aristolochiae or Guanxin Suhe Wan for a long term in rats

目的:评价青木香的毒性,为临床合理用药提供实验依据。方法:长期给予不同组大鼠2.5 g.kg-1的青木香、2.5 g.kg-1的冠心苏合丸(含青木香)和2.5 g.kg-1的冠心苏合丸(不含青木香),检测各组大鼠的凝血酶原时间(PT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、碱性磷酸酶(ALP)、肌酐(Crea)和尿素氮(BUN)等指标,并对肾脏、肝脏、胃和膀胱进行病理学检查。结果:青木香和冠心苏合丸(含青木香)组PT,ALT,AST,ALB,ALP,Crea和BUN等指标均发生显著性改变,病理检查发现肝、肾均有坏死现象,胃和膀胱均发生癌变。结论:青木香和冠心苏合丸(含青木香)具有强烈的毒性,均能损害大鼠的肾脏和肝脏,并引起胃和膀胱的肿瘤。

Objective： To evaluate the toxicity of Radix Aristolochiae supplied experimental evidence of rational use of drug in clinic. Method： After treatment with small dose Radix Aristolochiae, Guanxin Suhe Wan （ with Radix Aristolochiae） and Guanxin Suhe Wan （without Radix Aristolochiae） in different group for a long term, respectively, the biochemical indicator of PT, ALT, AST, ALB, ALP, Crea and BUN were detected, and the kidney, liver, stomach and urinary bladder were examined by pathologic assaying. Result： In Radix Aristolochiae group and Guanxin Suhe Wan （with Radix Aristolochiae） group, all of biochemical indicator were changed significantly, and hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered. Conclusion： Radix Aristolochiae and Guanxin Suhe Wan （with Radix Aristolochiae） can damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity.