黄芩茎叶总黄酮调血脂作用及其机制的研究

Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism

目的:观察黄芩茎叶总黄酮(SSTF)对实验性高脂血症大鼠脂代谢的影响,初步探讨SSTF降脂机制。方法:在建立大鼠高脂血症模型基础上,观察SSTF对大鼠血脂水平、脂蛋白代谢酶、抗氧化能力等方面的影响。结果:SSTF能显著降低高脂血症大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)浓度,显著升高高密度脂蛋白胆固醇(HDL-C)和ApoAI浓度,提高血清卵磷脂胆固醇酰基转移酶(LCAT)的活性。SSTF能显著降低血清和肝脏丙二醛(MDA)含量,增加血清超氧化物歧化酶(SOD)的活性。结论:SSTF能明显调节高脂血症大鼠脂质代谢紊乱,对脂蛋白有一定的调节作用。提示SSTF可减少动脉粥样硬化的发生,其调脂机制初步认为与提高脂蛋白代谢酶LCAT的活性和提高抗氧化能力有关。

Objective： To investigate the effect and mechanism of Scutellaria Baicalensis Stem-leaf Total Flavonoid （SSTF） on lipid metabolism in hyperlipidemic rat. Method： On the basis of establishing hyperlipidemia rat model, blood lipids, lipid metabolic enzyme, antioxidative capacity were investigated after 30 days feeding of fatty emulsion. Result： SSTF significantly reduced the serum TC, TG, LDL-C, ApoB concentration and increased HDL-C and ApoAI levels, improved the activity of lecithin cholesterol acyltransferase （LCAT）. SSTF was shown to decreased MDA content in both serum and liver, increased serum SOD activity. Conclusion： SSTF could remarkably modulate the lipid metabolic disorder in hyperlipidemic rats, and has a certain regulating function on lipoprotein, inferring that it could reduce the occuring of atherosclerosis. The mechanism of regulating lipid metabolism might be related with the increasing activity of LCAT and antioxidative capacity.