临床试验Williams设计中样本含量的估算方法

Sample size calculation for Williams design in clinical trials

在临床试验中,2组交叉设计应用已相当广泛,其样本含量估算方法也被研究者所熟悉。多组交叉试验由Williams首先提出,因此被称为Wil-liams设计。本文介绍基于Williams设计的样本含量估算方法,并提供示例分析,供研究者参考使用。

Crossover design has been commonly used in clinical trials, the method of sample size calculation for crossover design has been well known. In resent years, the multiple crossover design, which is constructed by Williams, so called Williams design, is also used by researchers. In this paper, the method of sample size calculation for Williams design and practical samples are introduced.