皮肤消毒剂碘伏开启后有效使用期限研究

Period of Validity for Skin Disinfectant Povidone-iodine

目的探讨碘伏皮肤消毒剂原装塑料瓶开启后,在不同季节、不同使用时间和不同使用频率条件下的使用期限。方法分别在春秋两季,原装碘伏塑料瓶开启后在不同诊疗环境中10 d,每天每次使用后取瓶内碘伏消毒液适量进行有效碘含量、致病菌检测及染菌量测定。结果使用中的碘伏皮肤消毒剂随着使用时间的延长和使用频率的增加其有效碘的含量持续下降,春季有效碘平均衰减率为1.28%,秋季有效碘平均衰减率为0.83%,在不同季节有效碘的含量变化差异有统计学意义(P<0.01);消毒液在不同时间、季节和使用频率后未检出致病菌。结论在标准范围内,碘伏皮肤消毒剂原装塑料瓶开启后可以连续使用10 d。

OBJECTIVE To study the period of validity of iodine skin disinfectant povidone-iodine （Iodophor） in different seasons, different hours and different using frequency. METHODS In spring and summer respectively, the iodine was used for 10 days continually after the bottle opened. Then, the sample drawing from bottle was detected for iodine content, pathogenic bacteria and contamination of bacteria quantification. RESULTS The available iodine content was coming down gradually with the increasing in usage time and frequency. And the changing in the content differed in spring and summer. Microorganism was not found in povidone-iodine under using time,different seasons and using frequency. CONCLUSIONS The skin disinfectant can be used for 10 days at least under standard range after begining using.