医院感染凝固酶阴性葡萄球菌临床分布及耐药性调查

Distribution and Resistance of Coagulase-negative Staphylococcus

目的调查医院临床分离出的凝固酶阴性葡萄球菌(CNS)的分布特点及耐药状况,为医院感染的预防与控制提供可靠依据。方法采用ATB Expresson细菌鉴定及药物敏感系统对2005年10月-2007年9月住院患者各类标本分离的CNS进行鉴定和药敏试验。结果共分离到CNS 354株,主要来自分泌物、痰液、血液及脑脊液标本;以儿科、重症监护病房(ICU)和骨科、神经内科的住院患者为主,分别占9.90%、9.30%、9.00%和5.60%。结论CNS是临床感染的重要病原菌,耐药情况严峻,应对其进行严密监测,合理用药,积极预防医院感染的发生。

OBJECTIVE To provide laboratory evidence for the prevention and control of coagulase negative staphylococcus （CNS）, and study the distribution and drug resistance of CNS in our hospital. METHODS CNS of inpatients from Oct 2005 to Dec 2007 was isolated and identified with ATB Expression microbe identification and drug sensitivity system. RESULTS A total of 354 strains of CNS were isolated, from the main samples of secretion, sputum, blood and cerebrospinal fluid. The isolation rate from departments of pediatrics, ICU, orthopedics and neurology were 9.90 %,9.30 %, 9.00 % and 5.60 %, respectively. CONCLUSIONS CNS is playing a significant role in nosocomial infection. The drug resistance of CNS is very serious. To pevent nosocomial infection,it is critically important to monitor the antimicriobial resistance of CNS and use autibiotics more rationally.