中西医结合治疗中老年带状疱疹的临床观察

Integrative Medicinal Therapy on Herpes Zoster in Middle and Old Aged Patients

目的观察芩珠合剂联用伐昔洛韦治疗中老年带状疱疹患者的疗效。方法将97例中老年带状疱疹患者随机分入芩珠凉血合剂组、伐昔洛韦组、芩珠凉血合剂联用伐昔洛韦组(联合用药组),观察用药后止疱、结痂、止痛和痊愈的时间及后遗神经痛(postherpetic neuralgia,PHN)的发生率,同时对患者的症状和体征进行治疗前后评分。结果伐昔洛韦组止疱及结痂时间短于芩珠凉血合剂组;联合用药组的止痛及痊愈时间短于芩珠凉血合剂组,且PHN发生率低于另外两组。结论伐昔洛韦治疗带状疱疹起效较快;而芩珠凉血合剂则能有效缓解疼痛,与伐昔洛韦联合应用能有效减少PHN的发生。

Objective To study the therapeutic effect of integrative medicinal therapy with Qinzhu Liangxue Mixture （QLM） in combined with valaciclovir on herpes zoster （HZ） in middle and old aged patients. Methods Ninety-seven HZ patients were randomly assigned to three groups and treated respectively with QLM alone （A）, valaciclovir alone （B） and QLM plus valaciclovir （C）. Times for stopping newly appeared blisters, scabbing relieving pain, and curing, as well as incidence rate of postherpetic neuralgia （PHN） after treatment were evaluated. Patients＇ symptoms and signs were scored before and after treatment. Results Time for appeaed newly blister and scabbing was shorter in Group B than in Group A ; time for relieving pain and curing was shorter in Group C than in Group A; and the PHN incidence rate in Group C was the lowest. Conclusion Valaciclovir can control the skin rash of HZ with quicker initiating time, and QLM can effectively relieve pain, the combined use with the two drugs can decrease the incidence rate of PHN availably.